Shifting Medicine Forward

Our path toward disease-centric therapies

ONCOLOGY
Ichnos continues to advance its pipeline of multispecific antibodies in oncology.
Please connect with us at our Contact Us page if you are interested in exploring a partnership.
Asset Description Preclinical Phase 1 Phase 2 Phase 3 Status

Products
ISB 1342
CD38 x CD3
BEAT® 1.0 bispecific antibody
Multiple Myeloma;
T-ALL under consideration*
      Phase 1 Orphan Drug
ISB 1442
CD38 x CD47 BEAT® 2.0 bispecific antibody
Multiple Myeloma;
Phase 1 Acute Myeloid
Leukemia (AML) planned
      PHASE 1 Orphan Drug
ISB 2001
BCMA x CD38 x CD3 TREAT™ trispecific antibody
Multiple Myeloma
      PHASE 1 Orphan Drug

Candidates
ISB 2301
NK-cell engaging
multispecific platform
Solid Tumors
      Discovery

Products

Compound:
ISB 1342
Target:
CD38 x CD3
BEAT® 1.0 bispecific antibody
Indication:
Multiple Myeloma;
T-ALL under consideration*
Phase:
phase-1
Status:
Phase 1 Orphan Drug
Compound:
ISB 1442
Target:
CD38 x CD47 BEAT® 2.0 bispecific antibody
Indication:
Multiple Myeloma;
Phase 1 Acute Myeloid
Leukemia (AML) planned
Phase:
phase-1
Status:
PHASE 1 Orphan Drug
Compound:
ISB 2001
Target:
BCMA x CD38 x CD3 TREAT™ trispecific antibody
Indication:
Multiple Myeloma
Phase:
phase-1
Status:
PHASE 1 Orphan Drug

Candidates

Compound:
ISB 2301
Target:
NK-cell engaging
multispecific platform
Indication:
Solid Tumors
Phase:
preclinical
Status:
Discovery

*Will be advanced with a partner

BEAT®: Bispecific Engagement by Antibodies based on the TCR
TREAT™: Trispecific Engagement by Antibodies based on the TCR

 
Autoimmune Disease
Ichnos is out-licensing its autoimmune disease assets to enable greater focus on oncology. Explore the pipeline chart below to learn more and connect with us at our Contact Us page for additional information.
Products Description Preclinical Phase 1 Phase 2 Phase 3 Status
ISB 830 (telazorlimab) (Licensed to Astria Therapeutics)
OX40 antagonist monoclonal antibody
Atopic Dermatitis (AD)*
      Phase 2b completed†
ISB 880 / ALM27134 (Licensed to Almirall S.A.)
IL-1RAP antagonist monoclonal antibody
Autoimmune Disease
      Phase 1
Autoimmune Disease
Compound:
ISB 830 (telazorlimab) (Licensed to Astria Therapeutics)
Target:
OX40 antagonist monoclonal antibody
Indication:
Atopic Dermatitis (AD)*
Phase:
phase-2
Status:
Phase 2b completed†
Compound:
ISB 880 / ALM27134 (Licensed to Almirall S.A.)
Target:
IL-1RAP antagonist monoclonal antibody
Indication:
Autoimmune Disease
Phase:
phase-1
Status:
Phase 1
 

*A US IND for rheumatoid arthritis and other autoimmune indications is active.
†Primary efficacy endpoint (EASI score, % change, baseline to week 16) met at two highest doses tested. Numerical improvements were seen for the two higher-dose arms (300 mg and 600 mg q 2 weeks) of telazorlimab compared to placebo in the secondary endpoints of EASI-75 and Investigator Global Assessment, but the differences were generally not statistically significantly different from placebo.

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Career Opportunities

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